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The combined insulin and sulfonylurea therapy in diabetes of elderly people

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The combined insulin and sulfonylurea therapy in diabetes of elderly people

Auteurs : A. Quatraro [Italie] ; G. Consoli [Italie] ; A. Minei [Italie] ; D. Pinto [Italie] ; A. Ceriello [Italie] ; M. Varricchio [Italie] ; D. Giugliano [Italie]

Source :

Archives of Gerontology and Geriatrics [ 0167-4943 ] ; 1991.

RBID : ISTEX:1BD30C352A0A027DB7421C64274C75731861E3BE

English descriptors

Teeft :
- Adequate control, Antidiabetic therapy, Baseline values, Body weight, Chronic hyperglycemia, Combination therapy, Daily glycemic profile, Daily insulin, Daily insulin dose, Daily insulin doses, Dcct research group, Diabetes, Diabetes care, Diabetes mellitus, Diabetic, Diabetic patients, Elderly diabetics, Fasting, Glucose, Glucose metabolism, Glucose toxicity, Glycated hemoglobin, Glycemic, Glycemic profile, Hbalc, Initial period, Insulin, Insulin regimen, Insulin secretion, Insulin therapy, Insulin treatment, Metabolic, Metabolic control, Metabolic parameters, Observation period, Other hand, Peripheral hyperinsulinism, Plasma glucose, Positive results, Present study, Secondary failure, Sulfonylurea, Sulfonylurea gliclazide, Sulfonylurea therapy.

Abstract

Abstract: The usefulness and safety of the combined insulin-sulfonylurea (gliclazide) therapy were investigated in 70 elderly diabetic patients poorly controlled by insulin alone. More than half (45 diabetics, 64% of total) ameliorated significantly their metabolic control after six months of the combined treatment: not only the glycemic profile and glycated hemoglobin Alc were significantly decreased, but the daily insulin dose was reduced by approx. 35% (p < 0.01). These positive results in terms of improved glycemic control as well as reduction of daily insulin needs were still present after a mean period of follow-up of 5 years. The good percentage of positive results, the small incidence of hypoglycemic episodes and the consistent reduction of peripheral hyperinsulinism make this intervention (insulin-gliclazide) a safe strategy that can be adopted in a population of elderly diabetics, poorly controlled on insulin alone.

Url:

https://api.istex.fr/ark:/67375/6H6-ZQKGDV5X-N/fulltext.pdf

DOI: 10.1016/0167-4943(91)90046-S

Affiliations:

Italie

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: The usefulness and safety of the combined insulin-sulfonylurea (gliclazide) therapy were investigated in 70 elderly diabetic patients poorly controlled by insulin alone. More than half (45 diabetics, 64% of total) ameliorated significantly their metabolic control after six months of the combined treatment: not only the glycemic profile and glycated hemoglobin Alc were significantly decreased, but the daily insulin dose was reduced by approx. 35% (p < 0.01). These positive results in terms of improved glycemic control as well as reduction of daily insulin needs were still present after a mean period of follow-up of 5 years. The good percentage of positive results, the small incidence of hypoglycemic episodes and the consistent reduction of peripheral hyperinsulinism make this intervention (insulin-gliclazide) a safe strategy that can be adopted in a population of elderly diabetics, poorly controlled on insulin alone.</div>
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The combined insulin and sulfonylurea therapy in diabetes of elderly people

The combined insulin and sulfonylurea therapy in diabetes of elderly people

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri